Clinical Trials / Studies – Still Enrolling

Cancer

MEASURABLE Canine Oral Melanoma - Fully Enrolled

 A fully-funded trial evaluating a novel immunotherapy product for measurable canine oral melanoma. Sorrento Valley hospital.

--Please contact Dr. Brenda Phillips at 858-875-7500 for more information.

Canine Osteosarcoma

 Canine osteosarcoma, fully funded trial evaluating a novel immunotherapy procedure. Either Sorrento Valley or San Marcos hospitals. A pre-amputation consult is required but a pre-consult histologic/cytologic diagnosis is not necessary.

--Please contact Dr. Brenda Phillips at 858-875-7500 or Dr. Andi Flory at 760-466-0600 for more information.

Lymphoma Trials

 We are now enrolling eligible canine participants with peripheral lymph node lymphoma in a new study to evaluate the benefit of corticosteroids. To be eligible to participate in the trial, a lymphoma diagnosis has to be confirmed or must be highly suspected and chemotherapy treatment declined. Eligible dogs cannot have received any steroids before enrollment. The study provides FREE palliative prednisone.

--Please call Oncology Services at (858) 875-7500 or (760) 466-0600 with any questions.

Internal Medicine

Canine Bile Acid Diarrhea and Microbial Dysbiosis Study

*NEW* We are enrolling dogs with signs of inflammatory bowel disease, with or without histopathologic evidence, that are on current standard therapies (prednisone, diet) but continue to have diarrhea. A GI panel and fecal analysis for bile acid concertation and enteropathogens, along with a dysbiosis index will be performed through the GI Lab at Texas A&M. Dogs with a non-GI disease to explain their sign will be excluded. Patients will be randomly assigned into a placebo or cholestyramine group. Owners will be asked to grade their dog’s feces daily. Dogs will be re-evaluated at 3, 6, and 16 weeks post induction of therapies. At these rechecks, a fecal sample will be collected and submitted for a fecal bile acid analysis and microbial evaluation. All study related expenses will be funded. Cost to initial diagnosis of a chronic enteropathy will be covered by clients.

--Contact Drs. John Gil or Steve Hill at (858) 875-7500

Clinical Trial for Diabetic Dogs

VSH is participating in an exciting new clinical trial using a novel stem cell therapy to resolve diabetes mellitus in dogs! Dogs must weigh 5 to 12 kg, and be free of significant other systemic illnesses, on insulin (preferably Vetsulin), and at least partially controlled. Owners must be willing to perform glucose curves at home (with training), and to reliably bring the dog in for follow-up visits over 3 years. All study-associated costs are covered for the study duration (labs, procedures, insulin, glucometer, exams, etc.), including the initial screening visit, so we encourage any potential candidates to come in for formal screening with Drs. Loy Son, Gil, Dong, or Fischer.

--Visit website for additional details or call (858) 875-7500. 

Feline IBD/GI Small Cell Lymphoma Study and Proteomics Study

We are enrolling cats with chronic gastrointestinal disease that are suspected of having either inflammatory bowel disease (IBD) or gastrointestinal small cell lymphoma (GI SC LSA). Endoscopy will be performed and GI biopsies will be obtained for histopathology, immunohistochemistry (IHC) and PCR for antigen receptor rearrangements (PARR). A 3 week follow-up will be required. Blood, urine, and fecal samples will be collected for proteomic analysis at the time of endoscopy and follow-up visit. The cost of the histopathology, IHC and PARR is funded. GI panel is also funded by the proteomic study.

--Contact Drs. Betty Chow, Steve Hill or Keith Richter at (858) 875-7500

Glucocorticoids and spec cPL study

Patients who will be started on glucocorticoids (minimum dose of 0.5mg/kg/day) and will need to be on them for at least 3 weeks. Patients will receive a spec cPL prior to administration of any glucocorticoids and at least 3 weeks after starting glucocorticoid therapy at no charge. Patients are being enrolled in North County and Sorrento Valley.

--Please call Drs. Sarah Cocker or Keith Richter at (858) 875-7500.