Clinical Trials / Studies – Still Enrolling


MEASURABLE Canine Oral Melanoma - Fully Enrolled

 A fully-funded trial evaluating a novel immunotherapy product for measurable canine oral melanoma. Sorrento Valley hospital.
--Please call Oncology Services at 858-875-7500 with any questions.

Canine Osteosarcoma 

Canine osteosarcoma, fully funded trial evaluating a novel immunotherapy procedure. Either Sorrento Valley or San Marcos hospitals. A pre-amputation consult is required but a pre-consult histologic/cytologic diagnosis is not necessary.

--Please call Oncology Services at (858) 875-7500 or (760) 466-0600 with any questions.

Lymphoma Trials

We are now enrolling eligible canine participants with peripheral lymph node lymphoma in a new study to evaluate the benefit of corticosteroids. To be eligible to participate in the trial, a lymphoma diagnosis has to be confirmed or must be highly suspected and chemotherapy treatment declined. Eligible dogs cannot have received any steroids before enrollment. The study provides FREE palliative prednisone.

--Please call Oncology Services at (858) 875-7500 or (760) 466-0600 with any questions.


Clinical Trial for Atopic Dogs

*NEW* Dr. Laura Stokking is enrolling canine patients in a new clinical trial for atopic dogs. Patients cannot have had any long-acting treatments for allergy, such as glucocorticoid injections or Cytopoint. Food allergy should have been ruled out prior to enrollment.

--For more information please contact Dermatology at (858) 875-7500. 

Emergency & Critical Care

Novel Rattlesnake Antivenom

*NEW* We are currently enrolling dogs that have been bitten (or suspected to have been bitten) by a rattlesnake for treatment with a novel antivenom. Enrolled dogs will receive free bloodwork on presentation (CBC, chemistry, coagulation panel) and trial antivenom at no cost to the client. Patients are required to return for a 24 hour post-antivenom administration recheck and free bloodwork (CBC, chemistry, coagulation panel). Owners must commit to the 24 hour recheck as well as use of their pet’s photos and/or videos for research and publication purposes. Patients are now being enrolled at Sorrento Valley, and North County enrollment begins August 14.

--For more information please contact Emergency and Critical Care at (858) 875-7500. 

Internal Medicine

Canine Bile Acid Diarrhea and Microbial Dysbiosis Study

*NEW* We are enrolling dogs with signs of inflammatory bowel disease, with or without histopathologic evidence, that are on current standard therapies (prednisone, diet) but continue to have diarrhea. A GI panel and fecal analysis for bile acid concertation and enteropathogens, along with a dysbiosis index will be performed through the GI Lab at Texas A&M. Dogs with a non-GI disease to explain their sign will be excluded. Patients will be randomly assigned into a placebo or cholestyramine group. Owners will be asked to grade their dog’s feces daily. Dogs will be re-evaluated at 3, 6, and 16 weeks post induction of therapies. At these rechecks, a fecal sample will be collected and submitted for a fecal bile acid analysis and microbial evaluation. All study related expenses will be funded. Cost to initial diagnosis of a chronic enteropathy will be covered by clients.

--Contact Internal Medicine Service (858) 875-7500

Clinical Trial for Diabetic Dogs

VSH is participating in an exciting new clinical trial using a novel stem cell therapy to resolve diabetes mellitus in dogs! Dogs must weigh 5 to 12 kg, and be free of significant other systemic illnesses, on insulin (preferably Vetsulin), and at least partially controlled. Owners must be willing to perform glucose curves at home (with training), and to reliably bring the dog in for follow-up visits over 3 years. All study-associated costs are covered for the study duration (labs, procedures, insulin, glucometer, exams, etc.), including the initial screening visit, so we encourage any potential candidates to come in for formal screening with Drs. Loy Son, Gil, Dong, or Fischer.

--Click here for additional details or call (858) 875-7500.

Feline IBD/GI Small Cell Lymphoma Study and Proteomics Study.

We are enrolling cats with chronic gastrointestinal disease that are suspected of having either inflammatory bowel disease (IBD) or gastrointestinal small cell lymphoma (GI SC LSA). Endoscopy will be performed and GI biopsies will be obtained for histopathology, immunohistochemistry (IHC) and PCR for antigen receptor rearrangements (PARR). A 3 week follow-up will be required. Blood, urine, and fecal samples will be collected for proteomic analysis at the time of endoscopy and follow-up visit. The cost of the histopathology, IHC and PARR is funded. GI panel is also funded by the proteomic study.
--For more information, please ask your family veterinarian to contact Drs. Betty Chow or Steve Hill at (858) 875-7500 to discuss details and eligibility prior to you scheduling a consultation.

Glucocorticoids and spec cPL study

Patients who will be started on glucocorticoids (minimum dose of 0.5mg/kg/day) and will need to be on them for at least 3 weeks. Patients will receive a spec cPL prior to administration of any glucocorticoids and at least 3 weeks after starting glucocorticoid therapy at no charge. Patients are being enrolled in North County and Sorrento Valley.

--For more information please contact Internal Medicine at (858) 875-7500.

Glomerular Disease Study

VSH is participating in a multi-center prospective study evaluating increased dosing of enalapril in dogs with glomerular disease. Client incentives include reduced cost of some initial testing and no cost for scheduled recheck visits and tests.

--For more information please contact Internal Medicine at (858) 875-7500.


Novel Rattlesnake Antivenom

*NEW* Clinical trial on tarsal replacement surgery. Dogs greater than 30kg with end stage osteoarthritis of the Tarsus.

--For more information please contact Surgery at (858) 875-7500. 

For a list of clinical trials across the Nation go to